Shinghua Ding, Cramer W. LaPierre Professor
Biomedical, Biological and Chemical Engineering
- Ph.D., Chemical and Biological Engineering, State University of New York at Buffalo, Buffalo, N.Y.
- Ding is the Cramer W. LaPierre Endowed Professor in the Department of Biomedical, Biological and Chemical Engineering and an investigator at the Dalton Cardiovascular Research Center at the University of Missouri-Columbia. His current research is focusing on:
- Glial cell function and neuron-glia interactions in central nervous system. In addition to neurons, other types of brain cells, generally called glia. Glial cell includes three subtypes: oligodendrocytes, microglia and astrocytes. Ding is interested in how astrocytes respond to pathological stimulations, specifically the alteration of Ca2+ signaling and its effect on neuronal function since Ca2+ elevation in astrocyte causes the release of neurotransmitters. He uses two-photon microscopy to imaging Ca2+ signaling in vivo and electrophysiology to record electric signal in our study.
- Stem cell differentiation and transplantation. The discovery of stem cells that can generate neuronal tissue has raised new possibilities for repairing the nervous system. The key to the success of neuron-replacement therapies is the integration of transplanted cells into the host nervous system. Ding’s goal is to understand the mechanism of stem cell differentiation and study the function of stem cells after differentiation. He uses electrophysiology, fluorescent imaging and immunocytochemistry to achieve our goal. Ultimately, Ding will transplant stem cells into mouse brain to study the therapeutic effect of stem cell on neurodegenerative disease.
- Ion channel function and modulation. Ion channels are membrane proteins that can close and open in response to membrane potential change, ligand binding and mechanical force. The channels allow ions to flow down to electrochemical potential to produce electrical signal, activate signal transduction pathways, regulate cell volume, and mediate fluid and electrolyte transport. Ding is interested in studying the function and modulation of ion channel using electrophysiology and molecular biology.
- BE 4570/7570, Biomedical Imaging