September 21, 2021
Eric Stann / MU News Bureau
The consequences are dire for the health of a premature baby — too much oxygen can cause blindness, and too little oxygen can cause brain damage and other negative health effects.
Some premature babies need the help of life-saving machines in a neonatal intensive care unit, or NICU, to provide oxygen that eases the struggle to take their first breaths. However, small, personalized adjustments — to either raise or lower the level of oxygen provided — must be made by hand under the careful attention of nurses and respiratory therapists. Now, a clinical trial will test a new device, designed by a researcher at the University of Missouri College of Engineering, that could make those needed adjustments for premature babies in a NICU — automatically.
Roger Fales, an associate professor of mechanical and aerospace engineering and associate dean in the College of Engineering, who designed the device, compares it to the way cruise control works in a vehicle.
“On the automobile, cruise control automates the process of keeping the speed constant in your vehicle, even as the vehicle goes up and down hills,” Fales said. “In the case that we have here, we’re automating the process of adjusting the amount of oxygen that the baby receives to keep their blood oxygen saturation constant. The more consistently we can control the oxygen, the better the baby is, and the faster the baby is going to be able to develop. Plus, there will be fewer events that are detrimental to the baby’s health.”
John Pardalos, an associate professor in the Department of Child Health in the MU School of Medicine, who is helping oversee the clinical aspects of the trial, said one projected outcome of the study will be examining how well the device performs as compared to the current manual procedure.
“The thing that we’ll look at is what kept the oxygen level in the prescribed range the most, the nurses or the computer,” Pardalos said. “We have very tight parameters for the oxygen levels that the nurses and the respiratory therapists must ensure are met.”
“Without having the ability to collaborate with good people at MU Health Care and the MU School of Medicine, this sort of collaboration would not be possible,” Fales said. “It really takes both engineers and medical doctors to be able to put this this kind of project together.”
The project will also create opportunities for engineering students at MU to have a hands-on learning experience, Fales said.
“Not every student in engineering gets to go to a hospital and see something in action,” Fales said. “Having the experience and opportunity to develop a medical device in our lab on the University of Missouri campus, and then take that device over to the NICU and work directly with the neonatologist, is going to set us up for not only producing research results, but also educating the students that are involved. They’re a big part of this project, and gaining this kind of experience is going to allow them to work within medical-specific areas within engineering and also demonstrate and build skills for working in multiple disciplinary teams that can be useful anywhere within engineering — or outside of engineering as well.”
Funding is provided by a grant from Child Health and Human Development at the National Institutes of Health and a grant from the University of Missouri Coulter Translational Partnership.
Learn more at Show Me Mizzou.